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“Finally Hopeful is a groundbreaking book that redefines how we understand and treat depression. Dr. James Greenblatt brilliantly brings the lens of functional psychiatry to one of the most pervasive and misunderstood conditions of our time. Instead of masking symptoms with a one-size-fits-all approach, he offers a personalized, root-cause strategy that integrates nutrition, biology, and the brain-body connection. This is the future of mental health—one that offers real healing, not just hope. If you or someone you love struggles with depression, this book is essential reading.”

   – Mark Hyman, MD, #1 New York Times bestselling author of Young Forever and The UltraMind Solution

Major depression is one of the most common mental illnesses, affecting more than 21 million American adults and 3.7 million of our youth each year. And yet, the current one-size-fits-all medical model for psychiatric treatment of depression does not work for a significant portion of patients. Antidepressant medications are often treated as a magic bullet, but the truth is that depression is a complex mental and physical condition, influenced by nutrient intake and absorption, body chemistry, metabolism, genetics, hormones, food sensitivities, stressful life events, social support, and many other factors.

In Finally Hopeful, functional psychiatrist Dr. James Greenblatt offers a new model of treatment that acknowledges that depression is not “all in your head,” but in your body. Dr. Greenblatt provides a unique guide to optimizing the nutrients, hormones, neurotransmitters, and many other biochemical factors that play a major role in most cases of depression. It is vital to address these physical factors using testing that customizes treatment to the individual, and Finally Hopeful outlines what tests you need; how to read the results for practical action; and how to work in conjunction with your physician. You’ll also gain key insights into antidepressants and feel empowered in seeking the answers you deserve.

A functional psychiatry approach recognizes that depression has many causes and often requires a range of therapies, both drug and non-drug. Finally Hopeful makes the whole-body approach available to everyone, delivering real hope and relief.

Additional Praise

“Finally Hopeful is a powerful, science-based guide that echoes what I’ve seen in over thirty years of brain imaging and clinical practice: depression and hopelessness are not moral failings — they are medical conditions with real, treatable causes. Dr. Greenblatt provides the kind of practical, personalized strategies we need to create a national brain health revolution.”
   – Daniel G. Amen, MD, Founder, Amen Clinics, Author of Change Your Brain Every Day
“Finally Hopeful is a beacon of hope for anyone who has felt trapped in the revolving door of traditional psychiatric treatment. In this timely and transformative book, Dr. James Greenblatt boldly dismantles the outdated paradigm that seeks only to suppress symptoms with one-size-fits-all medications. Instead, he illuminates a new path, one grounded in functional psychiatry, that addresses the actual root causes of depression. By integrating cutting-edge science with personalized care, Dr. Greenblatt offers real healing rather than temporary relief. His approach recognizes that mental health is deeply connected to biology, nutrition, and the brain-body connection. This book is not just a hopeful vision it is the future of mental health care. For patients, families, and clinicians alike, Finally Hopeful is a must-read guide to meaningful, lasting recovery.”
   – David Perlmutter, board-certified neurologist and #1 New York Times bestselling author of Grain Brain